FSL 1

Tocris Bioscience | Catalog # 6011

TLR2/6 agonist (also a putative TLR10 ligand)
Tocris Bioscience
Discontinued Product
6011 has been discontinued. View all Toll-like Receptor Agonists products.

Key Product Details

Description

TLR2/6 agonist (also a putative TLR10 ligand)
View all Toll-like Receptor Agonists »

Product Description

FSL 1 is a TLR2/6 agonist (also a putative TLR10 ligand). Activates NF-κB. Induces pro-inflammatory cytokines including IL-8, IL-1β, CCL20 and TNF-α in vitro. Synergizes with IFNγ to induce CXCL10 release from melanoma cells.

Product Specifications for FSL 1

Molecular Weight

1666.16

Formula

C84H140N14O18S

Storage

Store at -20°C

Purity

≥95% (HPLC)

CAS Number

322455-70-9

PubChem ID

87858248

InChI Key

VJJLLNHELGKSNA-YWKNMTRCSA-N

SMILES

CCCCCCCCCCCCCCCC(=O)OCC(CSC[C@@H](C(=O)NCC(=O)N[C@@H](CC(=O)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC2=CN=CN2)C(=O)N3CCC[C@H]3C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC4=CC=CC=C4)C(=O)O)N)OC(=O)CCCCCCCCCCCCCCC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solubility Soluble to 2mg/ml in water

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Background References

References are publications that support the biological activity of the product.

Product Documents for FSL 1

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for FSL 1

For research use only

Customer Reviews for FSL 1 (1)

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  • FSL-1 works well for inducing TLR2 signaling
    Name: Xiaogang Wang
    Species: Human
    Assay Type: In Vitro
    Cell Line/Tissue: THP-1
    Verified Customer | Posted 09/15/2020
    We used this molecule to serve as a control to induce TLR2 signaling. The differentiated THP-1 macrophages were treated with FSL-1 for staphylococcus aureus lipoproteins for 4 h and the TNFa in culture supernatants was measured by ELISA.
    FSL 1 6011

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