FTBMT

Key Product Details

Product Description

FTBMT (also known as TP 024) is a potent and selective GPR52 agonist (EC₅₀ = 75 nM, E_max = 122%), which is selective for GPR52 over a panel of 98 targets including D₁, D₂, AMPA and NMDA. FTBMT suppresses methamphetamine-induced hyperlocomotion in mice, and inhibits MK-801-induced hyperactivity (model for acute psychosis), without causing catalepsy in mice. This compound is orally bioavailable and brain penetrant.

External Portal Information

Chemicalprobes.org

and the Chemical Probes webpages of the Structural Genomics Consortium are portals that offer independent guidance on the selection and/or application of small molecules for research. The use of FTBMT (TP 024) is reviewed on chemicalprobes.org and the SGC website.

Product Specifications for FTBMT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for FTBMT

The following data is based on the product molecular weight 392.35.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

4 3 2 1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.55 mL	12.74 mL	25.49 mL
5 mM	0.51 mL	2.55 mL	5.10 mL
10 mM	0.25 mL	1.27 mL	2.55 mL
50 mM	0.05 mL	0.25 mL	0.51 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Nishiyama FTBMT, a novel and selective GPR52 agonist, demonstrates antipsychotic-like and procognitive effects in rodents, revealing a potential therapeutic agent for schizophrenia. J.Pharmacol.Exp.Ther. 2017 PMID: 28851764
• Tokumaru Design, synthesis, and pharmacological evaluation of 4-azolyl-benzamide derivatives as novel GPR52 agonists. Bioorg.Med.Chem. 2017 PMID: 28433511

Product Documents for FTBMT