FzM1.8

Key Product Details

Product Description

FzM1.8 is a frizzled 4 allosteric agonist (pEC₅₀ = 6.4). Potentiates the β-catenin pathway in the absence of any WNT ligand, by biasing FZD4 signaling toward the FZD4/PI3K axis. Preserves stemness and promotes proliferation of undifferentiated cells.

Product Specifications for FzM1.8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for FzM1.8

The following data is based on the product molecular weight 322.32.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.10 mL	15.51 mL	31.03 mL
5 mM	0.62 mL	3.10 mL	6.21 mL
10 mM	0.31 mL	1.55 mL	3.10 mL
50 mM	0.06 mL	0.31 mL	0.62 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Riccio A negative allosteric modulator of WNT receptor frizzled 4 switches into an allosteric agonist. Biochemistry 2018 PMID: 29293331

Product Documents for FzM1.8