G-15

Tocris Bioscience | Catalog # 3678

High affinity and selective GPER antagonist
Tocris Bioscience

Key Product Details

Description

High affinity and selective GPER antagonist
View all Estrogen and Related Receptor Antagonists »

Product Description

G-15 is a high affinity and selective GPER receptor antagonist (Ki = 20 nM) that displays no affinity for ERα and ERβ at concentrations up to 10 μM. Inhibits agonist-induced calcium mobilization in vitro (EC50 of ~185 nM) and antagonizes the antidepressive and renoprotective effects of estrogen in vivo.

Product Specifications for G-15

Molecular Weight

370.24

Formula

C19H16BrNO2

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

(3aS*,4R*,9bR*)-4-(6-Bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta[c]quinoline

CAS Number

1161002-05-6

PubChem ID

90488870

InChI Key

LBBDCJLRQXMUAE-FWHYVADDSA-N

SMILES

BrC1=CC4=C(OCO4)C=[C@@]1[C@@H]2NC(C=CC=C5)=C5[C@@]3([H])[C@@]([H])2CC=C3.BrC6=CC9=C(OCO9)C=[C@@]6[C@H]7NC(C=CC=C%10)=C%10[C@]8([H])[C@]([H])7CC=C8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 18.51 50

Preparing Stock Solutions for G-15

The following data is based on the product molecular weight 370.24.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 5.40 mL 27.01 mL 54.02 mL
2.5 mM 1.08 mL 5.40 mL 10.80 mL
5 mM 0.54 mL 2.70 mL 5.40 mL
25 mM 0.11 mL 0.54 mL 1.08 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 165 publications citing the usage of this product.

Product Documents for G-15

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for G-15

For research use only

Customer Reviews for G-15 (1)

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  • G-15 as inhibitor of gper30 in rat endothelial cells
    Name: Anonymous
    Species: Rat
    Assay Type: In Vitro
    Cell Line/Tissue: endothelial cell primary culture
    Verified Customer | Posted 01/04/2018
    I order this product from chile
    i used to blocked the gper30 receptor in endothelial cell culture to quantificate if estradiol and metabolites induce mobilization of calcium

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