Galangin

Key Product Details

Product Description

Galangin is a TRPC5 inhibitor. Inhibits Ca²⁺ entry into TRPC5 expressing cells. Inhibits LPS-induced expression of TNFα, IL-6, IL-1β, COX2 and iNOS, in vitro. Attenuates microglial activation, loss of dopaminergic neurons and motor dysfunction in a LPS-induced rat model of Parkinson's disease. Also inhibits proliferation in breast cancer cell lines. Induces autophagy. Also displays antiviral activity against HSV-1, coxsackie B virus type 1, adenovirus type 31 and reovirus.

Product Specifications for Galangin

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Galangin

The following data is based on the product molecular weight 270.24.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.70 mL	18.50 mL	37.00 mL
5 mM	0.74 mL	3.70 mL	7.40 mL
10 mM	0.37 mL	1.85 mL	3.70 mL
50 mM	0.07 mL	0.37 mL	0.74 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Meyer Antiviral activity of galangin isolated from the aerial parts of Helichrysum aureonitens. J.Ethnopharmacol. 1997 PMID: 9174978
• Wen Galangin induces autophagy through upregulation of p53 in HepG2 cells. Pharmacology. 2012 PMID: 22507894
• Chen Galangin reduces the loss of DArgic neurons in an LPS-evoked model of Parkinson's disease in rats. Int.J.Mol.Sci. 2017 PMID: 29267220
• So Inhibition of human breast cancer cell proliferation and delay of mammary tumorigenesis by flavonoids and citrus juices. Nutr.Cancer. 1996 PMID: 8875554
• Naylor Natural and synthetic flavonoid modulation of TRPC5 channels. Br.J.Pharmacol. 2016 PMID: 26565375

Product Documents for Galangin