GANT 61

Key Product Details

Product Description

GANT 61 is a GLI antagonist that inhibits GLI1 and GLI2-induced transcription (IC₅₀ ~ 5 μM). Inhibits the hedgehog (Hh) signaling pathway downstream of SMO and SUFU causing GLI1 nuclear accumulation. Displays antiproliferative and antitumor activity in vivo. Inhibits the pluripotency factors Oct4, Sox-2, Nanog and c-Myc in pancreatic cancer stem cells.

Product Specifications for GANT 61

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for GANT 61

The following data is based on the product molecular weight 429.61.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.33 mL	11.64 mL	23.28 mL
5 mM	0.47 mL	2.33 mL	4.66 mL
10 mM	0.23 mL	1.16 mL	2.33 mL
50 mM	0.05 mL	0.23 mL	0.47 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 52 publications citing the usage of this product.

• Fu GANT-61 inhibits pancreatic cancer stem cell growth in vitro and in NOD/SCID/IL2R gamma null mice xenograft. Cancer Lett. 2012 PMID: 23200667
• Mazumdar Blocking Hedgehog survival signaling at the level of the GLI genes induces DNA damage and extensive cell death in human colon carcinoma cells. Cancer Res. 2011 PMID: 21747117
• Lauth Inhibition of GLI-mediated transcription and tumor cell growth by small molecule antagonists. Proc.Natl.Acad.Sci.USA 2007 PMID: 17494766

Product Documents for GANT 61