Gap 26

Name: Gap 26
Brand: Tocris Bioscience
SKU: 1950

Tocris Bioscience | Catalog # 1950

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Citations (116)

Product Documents

Gap junction blocker; inhibits smooth muscle contraction and IP3-mediated ATP release

Discontinued Product

1950 has been discontinued. View all Gap Channel Blockers products.

Product Description
Product Specifications
Solubility
Calculators
Background References
Product Documents
Specific Notices
Research Areas

Key Product Details

Description

Gap junction blocker; inhibits smooth muscle contraction and IP3-mediated ATP release

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Product Description

Gap 26 is a peptide, corresponding to residues 63 - 75 of connexin 43, which is a gap junction blocker. Attenuates rhythmic contractile activity of rabbit arterial smooth muscle (IC₅₀ = 28.4 μM). Also inhibits IP₃-induced ATP release, without inhibiting gap junctional coupling in endothelial cells.

Product Specifications for Gap 26

Molecular Weight

1550.79

Formula

C₇₀H₁₀₇N₁₉O₁₉S

Storage

Store at -20°C

Purity

≥95% (HPLC)

CAS Number

197250-15-0

PubChem ID

25088334

InChI Key

FDPIMWZHGJNESB-VCSXYVMHSA-N

SMILES

[H]N[C@@H](C(C)C)C(=O)N[C@@H](CS)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N1CCC[C@H]1C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Soluble to 2mg/ml in water

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 116 publications citing the usage of this product.

Chaytor Peptides homologous to extracellular loop motifs of connexin 43 reversibly abolish rhythmic contractile activity in rabbit arteries. J.Physiol. 1997 PMID: 9288678
Braet Photoliberating inositol-1,4,5-trisphosphate triggers ATP release that is blocked by the connexin mimetic peptide gap 26. Cell Calcium 2003 PMID: 12526886

Product Documents for Gap 26

Certificate of Analysis

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Product Specific Notices for Gap 26

For research use only

Related Research Areas

Ion Channels and Regulators

Citations for Gap 26

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