Gap 27

Name: Gap 27
Brand: Tocris Bioscience
SKU: 1476
Price: 347 USD
Availability: InStock

Tocris Bioscience | Catalog # 1476

Submit a review

Citations (28)

Product Documents

Selective gap junction blocker

Product Description
Product Specifications
Solubility
Calculators
Background References
Product Documents
Specific Notices
Research Areas

Key Product Details

Description

Selective gap junction blocker

View all Gap Channel Blockers »

Product Description

Gap 27 is a peptide derived from connexin 43 that is a selective gap junction blocker. Attenuates ACh-induced arterial relaxation and reduces K⁺-mediated smooth muscle repolarization in endothelium-intact vessels in vitro.

Product Specifications for Gap 27

Molecular Weight

1304.55

Formula

C₆₀H₁₀₁N₁₅O₁₇

Storage

Store at -20°C

Purity

≥95% (HPLC)

CAS Number

198284-64-9

PubChem ID

9920128

InChI Key

SXRAPDIXXYFGJG-MDAHIHQXSA-N

SMILES

[H]N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Soluble to 1mg/ml in water

Calculators

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

音量

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 28 publications citing the usage of this product.

Ko Biochemical and functional characterization of intercellular adhesion and gap junctions in fibroblasts. Am.J.Physiol.Cell Physiol. 2000 PMID: 10898726
Richards Suppression of K⁺-induced hyperpolarization by phenylephrine in rat mesenteric artery: relevance to studies of endothelium-derived hyperpolarizing factor. Br.J.Pharmacol. 2001 PMID: 11522590
Chaytor Central role of heterocellular gap junctional communication in endothelium-dependent relaxations of rabbit arteries. J.Physiol. 1998 PMID: 9508817

Product Documents for Gap 27

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Download SDS

Product Specific Notices for Gap 27

For research use only

Related Research Areas

Ion Channels and Regulators

Citations for Gap 27

Customer Reviews for Gap 27

There are currently no reviews for this product. Be the first to review Gap 27 and earn rewards!

Have you used Gap 27?

Submit a review and receive an Amazon gift card!

$25/€18/£15/$25CAN/¥2500 Yen for a review with an image

$10/€7/£6/$10CAN/¥1110 Yen for a review without an image