Gap19

Name: Gap19
Brand: Tocris Bioscience
SKU: 5353
Price: 309 USD
Availability: InStock

Tocris Bioscience | Catalog # 5353

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Citations (29)

Product Documents

Cx43 hemichannel blocker

Product Description
Product Specifications
Solubility
Calculators
Background References
Product Documents
Specific Notices
Research Areas

Key Product Details

Description

Cx43 hemichannel blocker

View all Gap Channel Blockers »

Product Description

Gap19 is a selective connexin 43 (Cx43) hemichannel blocker; has no effect on gap junction coupling or Panx-1 channels. Reduces mitochondrial potassium influx in cardiomyocytes and attenuates glutamate-triggered ATP release in primary astrocytes. Modestly reduces infarct size in a mouse ischemia model.

Product Specifications for Gap19

Molecular Weight

1161.45

Formula

C₅₅H₉₆N₁₄O₁₃

Storage

Store at -20°C

Purity

≥95% (HPLC)

CAS Number

1507930-57-5

PubChem ID

91691126

InChI Key

IEAKEKFIXUZWEH-PKMKMBMKSA-N

SMILES

[H]N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCCCN)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Soluble to 2mg/ml in water

Calculators

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Mass

Concentration

音量

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g/mol

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Concentration 1 (C1)

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Concentration 2 (C2)

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The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 29 publications citing the usage of this product.

Wang Selective inhibition of Cx43 hemichannels by Gap19 and its impact on myocardial ischemia/reperfusion injury. Basic Res.Cardiol. 2013 PMID: 23184389
Abudara The connexin43 mimetic peptide Gap19 inhibits hemichannels without altering gap junctional communication in astrocytes. Front Cell Neurosci. 2014 PMID: 25374505
Boengler Connexin 43 impacts on mitochondrial potassium uptake. Front Pharmacol. 2013 PMID: 23760924

Product Documents for Gap19

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Download SDS

Product Specific Notices for Gap19

For research use only

Related Research Areas

Ion Channels and Regulators

Citations for Gap19

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