GDC 0879

Key Product Details

Product Description

GDC 0879 is a potent and selective B-Raf inhibitor (IC₅₀ = 0.13 nM against purified B-Raf ^V600E). Activity reduces phospho-ERK (pERK) levels (IC₅₀ = 63 nM in the Malme-3M cell line). Inhibits the Raf/MEK/ERK signaling pathway in V600E B-Raf mutant cell lines. Does not activate apoptotic pathways in A375 or Colo205 cell lines. Orally bioavailable.

External Portal Information

Chemicalprobes.org

is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of GDC 0879 is reviewed on the chemical probes website.

Product Specifications for GDC 0879

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for GDC 0879

The following data is based on the product molecular weight 334.37.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	29.91 mL	149.53 mL	299.07 mL
0.5 mM	5.98 mL	29.91 mL	59.81 mL
1 mM	2.99 mL	14.95 mL	29.91 mL
5 mM	0.60 mL	2.99 mL	5.98 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 7 publications citing the usage of this product.

• Hatzivassiliou RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth. Nature 2010 PMID: 20130576
• Hoeflich Antitumor efficacy of the novel RAF inhibitor GDC-0879 is predicted by BRAF^V600E mutational status and sustained extracellular signal-regulated kinase/mitogen-activated protein kinase pathway suppression. Cancer Res. 2009 PMID: 19276360
• Wong Pharmacodynamics of 2-{4-[(1E)-1-(hydroxyimino)-2,3-dihydro-1H-inden-5-yl]-3-(pyridine-4-yl)-1H-pyrazol-1-yl}ethan-1-ol (GDC-0879), a potent and selective B-Raf kinase inhibitor: understanding relationships between systemic conc J.Pharmacol.Exp.Ther. 2009 PMID: 19147858

Product Documents for GDC 0879