Geldanamycin

Tocris Bioscience | Catalog # 1368

Selective Hsp90 inhibitor
Tocris Bioscience

Key Product Details

Description

Selective Hsp90 inhibitor
View all HSP90 Inhibitors »

Product Description

Geldanamycin is a selectively inhibits heat shock protein 90 (Hsp90). Binds to the ATP site of Hsp90 (Kd = 1.2 μM) and inhibits its chaperone activity. Consequently inhibits activities of oncogenic kinases (e.g. src, Raf), p53 and steroid receptors. Demonstrates antiproliferative effect on breast cancer stem-like cells.

Product Specifications for Geldanamycin

Molecular Weight

560.64

Formula

C29H40N2O9

Storage

Desiccate at -20°C

Purity

≥98% (HPLC)

Chemical Name

9,13-Dihydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-2-azabicyclo[16.3.1]docosa-4,6,10,18,21-pentaene-3,20,22-trione, 9-carbamate

CAS Number

30562-34-6

PubChem ID

13017912

InChI Key

QTQAWLPCGQOSGP-PHLMVCJGSA-N

SMILES

O=C1C(OC)=C(C[C@@H](C)C[C@H](OC)[C@H](O)[C@@H](C)/C=C(C)/[C@H](OC(N)=O)[C@@H](OC)/C=C/C=C(C)/C2=O)C(C(N2)=C1)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 5.61 10

Preparing Stock Solutions for Geldanamycin

The following data is based on the product molecular weight 560.64.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 17.84 mL 89.18 mL 178.37 mL
0.5 mM 3.57 mL 17.84 mL 35.67 mL
1 mM 1.78 mL 8.92 mL 17.84 mL
5 mM 0.36 mL 1.78 mL 3.57 mL

Calculators

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Product Documents for Geldanamycin

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Geldanamycin

For research use only

Customer Reviews for Geldanamycin (2)

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  • Good Hsp90 blocker
    Name: Anonymous
    Species: Rat
    Assay Type: In Vitro
    Cell Line/Tissue: Primary hippocampal neurons
    Verified Customer | Posted 01/27/2023
    The drug was incubated at 10 μM to inhibit Hsp90.
  • Geldanamycin was used in resistance experiments
    Name: Anonymous
    Species: Human
    Verified Customer | Posted 02/27/2019
    Geldanamycin was used in resistance experiments. We investigated the Hsp90 family protein (HtpG) of the organism that makes GdA, S. hygroscopicus.
    Geldanamycin 1368

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