GF 109203X

Tocris Bioscience | Catalog # 0741

Protein kinase C inhibitor
Tocris Bioscience

Key Product Details

Description

Protein kinase C inhibitor

Alternative Names

Gö 6850,Bisindolylmaleimide I
View all Protein Kinase C Inhibitors »

Product Description

GF 109203X is a very potent and selective inhibitor of protein kinase C, selective for the α and β1 isoforms (IC50 values are 0.0084, 0.0180, 0.210, 0.132, and 5.8 μM for α, β1, δ, ε and ζ isoforms respectively). Selective over MLCK, PKG and PKA (IC50 values are 0.6, 4.6, and 33 μM respectively). Potent antagonist at the 5-HT3 receptor (Ki = 29.5 nM). Anti-inflammatory in vivo.

Product Specifications for GF 109203X

Molecular Weight

412.49

Formula

C25H24N4O2

Storage

Store at RT

Purity

≥98% (HPLC)

Chemical Name

2-[1-(3-Dimethylaminopropyl)indol-3-yl]-3-(indol-3-yl) maleimide

CAS Number

133052-90-1

PubChem ID

2396

InChI Key

QMGUOJYZJKLOLH-UHFFFAOYSA-N

SMILES

CN(C)CCCN1C=C(C2=CC=CC=C12)C1=C(C(=O)NC1=O)C1=CNC2=CC=CC=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 10.31 25

Preparing Stock Solutions for GF 109203X

The following data is based on the product molecular weight 412.49.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.25 mM 9.70 mL 48.49 mL 96.97 mL
1.25 mM 1.94 mL 9.70 mL 19.39 mL
2.5 mM 0.97 mL 4.85 mL 9.70 mL
12.5 mM 0.19 mL 0.97 mL 1.94 mL

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 317 publications citing the usage of this product.

Product Documents for GF 109203X

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for GF 109203X

For research use only

Related Research Areas

Diabetes
Intracellular Kinases

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  • GF 109203X blocks PKA effects in hippocampal neurons
    Name: Anonymous
    Species: Rat
    Assay Type: In Vitro
    Cell Line/Tissue: Hippocampus
    Verified Customer | Posted 07/21/2019
    GF 109203X (GF-109) was used to clarify an impact of PKC on average open time of GABA-A receptor channel. Experiment on outside-out membrane patches (OOP) and nucleated patches (NP) excised from hippocampal granule cells displayed a significant effect of GF-109 in NPs only. This confirms modulation of GABA-A receptor opening by PKA and ensures absence of GF-109 side effects on GABA-A receptors (since no effect was observed in OOPs).
    GF 109203X 0741

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