GLP-2 (3-33)

Name: GLP-2 (3-33)
Brand: Tocris Bioscience
SKU: 7725
Price: 393 USD
Availability: InStock

Tocris Bioscience | Catalog # 7725

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Peptide antagonist of glucagon-like peptide-2 (GLP-2) receptor

Technical Data
Reviews

Product Description
Product Specifications
Solubility
Calculators
Background References
Product Documents
Specific Notices

Key Product Details

Description

Peptide antagonist of glucagon-like peptide-2 (GLP-2) receptor

View all Glucagon-Like Peptide 2 Receptor Antagonists »

Product Description

GLP-2(3-33) is a peptide antagonist of glucagon-like peptide-2 (GLP-2) receptor. In cells, GLP-2(3-33) is generated by cleaving off the two N-terminal amino acids of GLP-2 with dipeptidylpeptidase IV (DPPIV). In high-fat diet (HFD) fed mice, GLP-2(3-33) treatment results in increased dyslipidemia and hepatic lipid accumulation. Chronic treatment of GLP-2(3-33) in HFD fed mice can cause hyperglycemia, glucose intolerance, high plasma insulin level after glucose load, increased pancreas weight and β-cell expansion.

Product Specifications for GLP-2 (3-33)

Molecular Weight

3557.93

Formula

C₁₅₆H₂₄₂N₄₀O₅₃S

Storage

Store at -20°C

Purity

≥90% (HPLC)

CAS Number

275801-62-2

PubChem ID

71455345

InChI Key

MYKFSDGCGNRIEA-KXTJMAPWSA-N

SMILES

O=C(NCC(N[C@@H](CO)C(N[C@@H](CC1=CC=CC=C1)C(N[C@@H](CO)C(N[C@@H](CC(O)=O)C(N[C@@H](CCC(O)=O)C(N[C@@H](CCSC)C(N[C@@H](CC(N)=O)C(N[C@@H]([C@H](O)C)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CC(C)C)C(N[C@@H](CC(O)=O)C(N[C@@H](CC(N)=O)C(N[C@@H](CC(C)C)C(N[C@@H](C)C(N[C@@H](C)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC(O)=O)C(N[C@@H](CC2=CC=CC=C2)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CC(N)=O)C(N[C@@H](CC3=CNC4=CC=CC=C34)C(N[C@@H](CC(C)C)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CCC(N)=O)C(N[C@@H]([C@H](O)C)C(N[C@@H](CCCCN)C(N[C@@H]([C@@H](C)CC)C(N[C@@H]([C@H](O)C)C(N[C@@H](CC(O)=O)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CC(O)=O)N

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Soluble to 2mg/ml in 0.01M PBS

Calculators

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Concentration

音量

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g/mol

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Background References

References are publications that support the biological activity of the product.

Baldassano Influence of endogenous glucagon-like peptide-2 on lipid disorders in mice fed a high-fat diet. Endocr.Res. 2016 PMID: 26906293
Baldassano GLP-2 involvement as a beneficial factor in the glucose homeostasis in mice fed a high fat diet. J.Cell Physiol. 2015 PMID: 25967277

Product Documents for GLP-2 (3-33)

Certificate of Analysis

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Product Specific Notices for GLP-2 (3-33)

For research use only

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