GLPG 0187

Key Product Details

Product Description

GLPG 0187 is a potent αv integrin inhibitor (IC₅₀ values are 1.2-3.7 nM). Inhibits osteoclastic bone resorption and angiogenesis in vitro and in vivo. Suppresses epithelial-mesenchymal transition (EMT) and migration of PC-3M-Pro4/luc cells, without inhibiting cell growth. Induces detachment and necrosis of GL-261 and SMA-560 murine glioma cells.

Product Specifications for GLPG 0187

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for GLPG 0187

The following data is based on the product molecular weight 595.71.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	16.79 mL	83.93 mL	167.87 mL
0.5 mM	3.36 mL	16.79 mL	33.57 mL
1 mM	1.68 mL	8.39 mL	16.79 mL
5 mM	0.34 mL	1.68 mL	3.36 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Silginer Integrin inhibition promotes atypical anoikis in glioma cells. Cell Death Dis. 2014 PMID: 24457956
• van der Horst, Targeting of αv-integrins in stem/progenitor cells and supportive microenvironment impairs bone metastasis in human prostate cancer. Neoplasia 2011 PMID: 21677875

Product Documents for GLPG 0187