GLPG 0974

Tocris Bioscience | Catalog # 5621

Potent FFA2 (GPR43) antagonist
Tocris Bioscience

Key Product Details

Description

Potent FFA2 (GPR43) antagonist
View all Free Fatty Acid Receptor Antagonists »

Product Description

GLPG 0974 is a potent FFA2 antagonist (IC50 = 9 nM). Exhibits selectivity for FFA2 over FFA3. Inhibits acetate-induced human neutrophil migration in plasma or buffer. Also inhibits FFA2-induced expression of CD11b activation-specific epitope (AE) in human whole blood. Orally bioavailable.

Product Specifications for GLPG 0974

Molecular Weight

485.00

Formula

C25H25ClN2O4S

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

4-[[[(2R)-1-(Benzo[b]thien-3-ylcarbonyl)-2-methyl-2-azetidinyl]carbonyl][(3-chlorophenyl)methyl]amino]butanoic acid

CAS Number

1391076-61-1

PubChem ID

57520598

InChI Key

MPMKMQHJHDHPBE-RUZDIDTESA-N

SMILES

O=C(N1[C@](C(N(CC2=CC(Cl)=CC=C2)CCCC(O)=O)=O)(C)CC1)C3=CSC4=C3C=CC=C4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 48.5 100
Ethanol 48.5 100

Preparing Stock Solutions for GLPG 0974

The following data is based on the product molecular weight 485.00.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.06 mL 10.31 mL 20.62 mL
5 mM 0.41 mL 2.06 mL 4.12 mL
10 mM 0.21 mL 1.03 mL 2.06 mL
50 mM 0.04 mL 0.21 mL 0.41 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 31 publications citing the usage of this product.

Product Documents for GLPG 0974

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for GLPG 0974

For research use only

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