Glybenclamide (NLRP3 Inhibitor)
Novus Biologicals | Catalog # NBP2-30141
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Key Product Details
Species
Human
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Product Specifications
Application Notes
Inhibition of NLRP3
Reactivity Notes
Human reactivity reported in scientific literature (PMID: 29680907).
Scientific Data Images for Glybenclamide (NLRP3 Inhibitor)
Glybenclamide (NLRP3 Inhibitor) [NBP2-30141] - Structure of the NLRP3 Inhibitor Glybenclamide: C23H28CIN3O5S
Formulation, Preparation, and Storage
Preparation Method
For multiple uses, we suggest aliquoting the stock solution prior to freezing. Bring the solution to room temperature before opening. Make further dilutions using sterile PBS. After reconstituted dilute further with sterilized PBS.
Reconstitute dilute further with sterilized PBS. Make a stock solution of 25 mg/ml of the NLRP3 inhibitor in high purity DMSO (>99.9%).
Reconstitute dilute further with sterilized PBS. Make a stock solution of 25 mg/ml of the NLRP3 inhibitor in high purity DMSO (>99.9%).
Formulation
Form : White Solid
Concentration
Lyoph
Shipping
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Storage
Store at -20C. Avoid freeze-thaw cycles.
Background: Glybenclamide
Alternate Names
glyburide, NLRP3 inhibitor
Additional Glybenclamide Products
Product Documents for Glybenclamide (NLRP3 Inhibitor)
Certificate of Analysis
To download a Certificate of Analysis, please enter a lot or batch number in the search box below.
Product Specific Notices for Glybenclamide (NLRP3 Inhibitor)
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Inhibitors are guaranteed for 1 year from date of receipt.
Citations for Glybenclamide (NLRP3 Inhibitor)
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Protocols
View specific protocols for Glybenclamide (NLRP3 Inhibitor) (NBP2-30141):
Glybenclamide (NLRP3 Inhibitor):
Material Safety Data Sheet for Glybenclamide
Hazard Information
Chemical Name Glybenclamide
Chemical Formula C23H28ClN3O5S
CAS Number 10238-21-8
EEC-No 233-570-6
Hazard Identification
Physical/chemical hazards
First Aid Measures
Eye Contact Check for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at least 15 minutes. Get medical attention.
Skin Contact In case of contact, immediately flush skin with plenty of water. Remove contaminated clothing and shoes. Wash clothing before reuse. Thoroughly clean shoes before reuse. Get medical attention.
Inhalation If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical attention.
Ingestion Do NOT induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious person. Loosen tight clothing such as a collar, tie, belt or waistband. Get medical attention if symptoms appear.
Accidental Release Measures
Splash goggles. Full suit. Boots. Gloves. Suggested protective clothing might not be sufficient; consult a specialist BEFORE handling this product. Use appropriate tools to put the spilled solid in a convenient waste disposal container. Use a shovel to put the material into a convenient waste disposal container. Finish cleaning by spreading water on the contaminated surface and allow to evacuate thorough the sanitary system.
Handling and Storage
Handling Keep away from heat. Keep away from sources of ignition. Empty containers pose a fire risk, evaporate the residue under a fume hood. Ground all equipment containing material. Do not ingest. Do not breathe dust. If ingested, seek medical advice immediately and show the container or the label. Keep container tightly closed. Keep container in a cool, well-ventilated area. Do not store above 20 degrees C (68 degrees F).Use original container.
Exposure Controls / Personal Protection
Respirator Wash hands after handling compounds and before eating, smoking, using lavatory, and at the end of day.
Ventilation yes
Gloves gloves
Eye Protection safty glasses
Other Precautions Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels low.
Physical and Chemical Properties
Form Powder
Color White
Odor Odorless
Melting Point No data available
Boiling Temperature No data available
Density No data available
Vapor Pressure No data available
Solubility in Water Very soluble
Flash Point No data available
Explosion limits No data available
Ignition Temperature No data available
Stability and Reactivity
The product is stable.
Toxicological Information
These products are carbon oxides (CO, CO2), nitrogen oxides (NO, NO2...), sulfur oxides (SO2, SO3...), halogenated compounds. Not considered to be toxic for humans.
Disposal Considerations
Waste must be disposed of in accordance with federal, state and local environmental control regulations.
Other Information
This product is not classified according to the EU regulations.
Material Safety Data Sheet for Glybenclamide
Hazard Information
Chemical Name Glybenclamide
Chemical Formula C23H28ClN3O5S
CAS Number 10238-21-8
EEC-No 233-570-6
Hazard Identification
Physical/chemical hazards
First Aid Measures
Eye Contact Check for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at least 15 minutes. Get medical attention.
Skin Contact In case of contact, immediately flush skin with plenty of water. Remove contaminated clothing and shoes. Wash clothing before reuse. Thoroughly clean shoes before reuse. Get medical attention.
Inhalation If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical attention.
Ingestion Do NOT induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious person. Loosen tight clothing such as a collar, tie, belt or waistband. Get medical attention if symptoms appear.
Accidental Release Measures
Splash goggles. Full suit. Boots. Gloves. Suggested protective clothing might not be sufficient; consult a specialist BEFORE handling this product. Use appropriate tools to put the spilled solid in a convenient waste disposal container. Use a shovel to put the material into a convenient waste disposal container. Finish cleaning by spreading water on the contaminated surface and allow to evacuate thorough the sanitary system.
Handling and Storage
Handling Keep away from heat. Keep away from sources of ignition. Empty containers pose a fire risk, evaporate the residue under a fume hood. Ground all equipment containing material. Do not ingest. Do not breathe dust. If ingested, seek medical advice immediately and show the container or the label. Keep container tightly closed. Keep container in a cool, well-ventilated area. Do not store above 20 degrees C (68 degrees F).Use original container.
Exposure Controls / Personal Protection
Respirator Wash hands after handling compounds and before eating, smoking, using lavatory, and at the end of day.
Ventilation yes
Gloves gloves
Eye Protection safty glasses
Other Precautions Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels low.
Physical and Chemical Properties
Form Powder
Color White
Odor Odorless
Melting Point No data available
Boiling Temperature No data available
Density No data available
Vapor Pressure No data available
Solubility in Water Very soluble
Flash Point No data available
Explosion limits No data available
Ignition Temperature No data available
Stability and Reactivity
The product is stable.
Toxicological Information
These products are carbon oxides (CO, CO2), nitrogen oxides (NO, NO2...), sulfur oxides (SO2, SO3...), halogenated compounds. Not considered to be toxic for humans.
Disposal Considerations
Waste must be disposed of in accordance with federal, state and local environmental control regulations.
Other Information
This product is not classified according to the EU regulations.
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