GNTI dihydrochloride

Tocris Bioscience | Catalog # 1282

Potent, selective κ antagonist
Tocris Bioscience
Discontinued Product
1282 has been discontinued. View all Kappa Opioid Receptor Antagonists products.

Key Product Details

Description

Potent, selective κ antagonist
View all Kappa Opioid Receptor Antagonists »

Product Description

GNTI dihydrochloride is a highly potent κ opioid receptor antagonist (Ki = 0.18 nM for human cloned κ receptors expressed in CHO cells). Displays 208- and 799-fold selectivity over μ and δ receptors respectively. Reduces feeding behavior in rats with a much higher potency (300-30,000-fold) and a shorter duration of action than nor-binaltorphimine (Cat.No. 0347).

Product Specifications for GNTI dihydrochloride

Molecular Weight

544.48

Formula

C27H29N5O3.2HCl

Storage

Desiccate at -20°C

Purity

≥96% (HPLC)

Chemical Name

5'-Guanidinyl-17-(cyclopropylmethyl)-6,7-dehydro-4,5α-epoxy-3,14-dihydroxy-6,7-2',3'-indolomorphinan dihydrochloride

CAS Number

351183-88-5

PubChem ID

90479777

InChI Key

GJPIMNXJPMPQHK-CVVXFVLRSA-N

SMILES

OC3=CC=C2CC([C@@]5(O)[C@@]4(CC8)C2=C3O[C@H]4C(NC7=C6C=C(NC=N)C=C7)=C6C5)N8CC1CC1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 54.45 100
DMSO 54.45 100

Preparing Stock Solutions for GNTI dihydrochloride

The following data is based on the product molecular weight 544.48.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.84 mL 9.18 mL 18.37 mL
5 mM 0.37 mL 1.84 mL 3.67 mL
10 mM 0.18 mL 0.92 mL 1.84 mL
50 mM 0.04 mL 0.18 mL 0.37 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 11 publications citing the usage of this product.

Product Documents for GNTI dihydrochloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for GNTI dihydrochloride

For research use only

Citations for GNTI dihydrochloride

Customer Reviews for GNTI dihydrochloride (1)

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  • Very Good Product
    Name: Luca Zangrandi
    Species: Human
    Assay Type: Ex Vivo
    Verified Customer | Posted 01/14/2020
    Successfully stopped selective agonist-induced ERK phosphorylation in CHO cells.
    GNTI dihydrochloride 1282

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