Go 6983

Tocris Bioscience | Catalog # 2285

Broad spectrum PKC inhibitor
Tocris Bioscience

Key Product Details

Description

Broad spectrum PKC inhibitor

Alternative Names

Goe 6983
View all Protein Kinase C Inhibitors »

Product Description

Go 6983 is a broad spectrum protein kinase C (PKC) inhibitor (IC50 values are 7, 7, 6, 10, 60 and 20000 nM for PKCα, PKCβ, PKCγ, PKCδ, PKCζ and PKCμ respectively). Displays cardioprotective properties; reduces polymorphonuclear leukocyte adherence and infiltration following myocardial ischemia/reperfusion injury. Optimizes naïve human pluripotent stem cell growth and viability following naïve cell derivation from primed ESCs and iPSCs using naïve human stem cell medium (NHSM).

Product Specifications for Go 6983

Molecular Weight

442.51

Formula

C26H26N4O3

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

3-[1-[3-(Dimethylamino)propyl]-5-methoxy-1H-indol-3-yl]-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione

CAS Number

133053-19-7

PubChem ID

3499

InChI Key

LLJJDLHGZUOMQP-UHFFFAOYSA-N

SMILES

O=C(N1)C(C2=CNC3=C2C=CC=C3)=C(C4=CN(CCCN(C)C)C5=C4C=C(OC)C=C5)C1=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 22.12 50

Preparing Stock Solutions for Go 6983

The following data is based on the product molecular weight 442.51.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 4.52 mL 22.60 mL 45.20 mL
2.5 mM 0.90 mL 4.52 mL 9.04 mL
5 mM 0.45 mL 2.26 mL 4.52 mL
25 mM 0.09 mL 0.45 mL 0.90 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 175 publications citing the usage of this product.

Product Documents for Go 6983

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Go 6983

For research use only

Related Research Areas

Diabetes
Intracellular Kinases

Customer Reviews for Go 6983 (2)

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  • Go 6983 blocks LPA-mediated COX-2 expression
    Name: Anonymous
    Species: Human
    Assay Type: In Vitro
    Cell Line/Tissue: Osteosarcoma
    Verified Customer | Posted 12/13/2018
    Human osteosarcoma cells were incubated with 20 μM Go 6983 for 30 min prior to treatment with 10 μM LPA to estimate COX-2 expression using Western blot analysis. Go 6983 abolished LPA-induced COX-2 expression.
    Go 6983 2285
  • Naive human pluripotent stem cell culture
    Name: Anonymous
    Species: Human
    Assay Type: In Vitro
    Cell Line/Tissue: pluripotent stem cells
    Verified Customer | Posted 05/31/2018
    Used for the culture of naive human pluripotent stem cells in t2iL+go media. Go 6983 used at 2µM concentration.

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