Home / 5-HT1D Receptor Agonists / GR 46611

GR 46611

Catalog #: 0864
1 Citation Datasheet / COA / SDS

Discontinued Product

0864 has been discontinued.
View all 5-HT1D Receptor Agonists products.
GR 46611 | CAS No. 185259-85-2 | 5-HT1D Receptor Agonists
1 Image
Description: 5-HT1D agonist

Chemical Name: 3-[3-(2-Dimethylaminoethyl)-1H-indol-5-yl]-N-(4-methoxybenzyl)acrylamide

Product Details
Citations (1)
Reviews
Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

GR 46611 is a 5-HT1D receptor agonist. Blockade of GR 46611-induced hypothermia in the guinea pig provides a useful model with which to study the potency and duration of action of centrally acting 5-HT1D receptor ligands.

Technical Data

M.Wt:
377.49
Formula:
C23H27N3O2
Solubility:
Soluble to 50 mM in DMSO and to 10 mM in ethanol
Storage:
Store at RT
CAS No:
185259-85-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold with the permission of GlaxoSmithKline

Background References

  1. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
    Fox JT, Sakamuru S, Huang R
    Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8.
  2. Serotonin is a key factor for mouse red blood cell survival.
    Amireault P, Bayard E, Launay J, Sibon D, Le Van Kim C, Colin Y, Dy M, Hermine O, Cote F
    PLoS ONE, 2013;8(12):e83010.
  3. Evolution of a novel series of [(N,N-Dimethylamino)propyl]- and piperazinylbenzanilides as the first selective 5-HT1D antagonists.
    Clitherow et al.
    J.Med.Chem., 1994;37:2253
  4. Stimulation of central 5-HT1D receptors causes hypothermia in the guinea pig.
    Skingle et al.
    J.Psychopharmacol., 1994;8:14

Product Datasheets

Certificate of Analysis is currently unavailable on-line. Please contact Customer Service
SDS
Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citation for GR 46611

The citations listed below are publications that use Tocris products. Selected citations for GR 46611 include:

1 Citation: Showing 1 - 1

  1. Effect of 5-hydroxytryptamine1 serotonin receptor agonists on noxiously stimulated micturition in cats with chronic spinal cord injury.
    Authors: Gu Et al.
    J Urol  2007;177:2381

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for GR 46611

There are currently no reviews for this product. Be the first to review GR 46611 and earn rewards!

Have you used GR 46611?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.