GR 46611

Key Product Details

Product Description

GR 46611 is a 5-HT_1D receptor agonist. Blockade of GR 46611-induced hypothermia in the guinea pig provides a useful model with which to study the potency and duration of action of centrally acting 5-HT_1D receptor ligands.

Licensing Information

Sold with the permission of GlaxoSmithKline

Product Specifications for GR 46611

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for GR 46611

The following data is based on the product molecular weight 377.49.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	5.30 mL	26.49 mL	52.98 mL
2.5 mM	1.06 mL	5.30 mL	10.60 mL
5 mM	0.53 mL	2.65 mL	5.30 mL
25 mM	0.11 mL	0.53 mL	1.06 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Skingle Stimulation of central 5-HT_1D receptors causes hypothermia in the guinea pig. J.Psychopharmacol.
• Clitherow Evolution of a novel series of [(N,N-Dimethylamino)propyl]- and piperazinylbenzanilides as the first selective 5-HT_1D antagonists. J.Med.Chem. 1994 PMID: 8057272

Product Documents for GR 46611