GRK2i

Name: GRK2i
Brand: Tocris Bioscience
SKU: 3594

Tocris Bioscience | Catalog # 3594

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Citations (14)

Product Documents

GRK2 inhibitory polypeptide; Gβ/γ antagonist

Discontinued Product

3594 has been discontinued. View all G Protein (Heterotrimeric) Inhibitors products.

Product Description
Product Specifications
Solubility
Calculators
Background References
Product Documents
Specific Notices

Key Product Details

Description

GRK2 inhibitory polypeptide; Gβ/γ antagonist

View all G Protein (Heterotrimeric) Inhibitors »

Product Description

GRK2i is a GRK2 inhibitory polypeptide that specifically inhibits Gβγ activation of GRK2. Corresponds to the Gβγ-binding domain and acts as a cellular Gβγ antagonist.

Product Specifications for GRK2i

Molecular Weight

3484.08

Formula

C₁₅₃H₂₅₆N₅₀O₄₁S

Storage

Store at -20°C

Purity

≥95% (HPLC)

CAS Number

148505-03-7

PubChem ID

90488863

InChI Key

QYWJBYYWQATYFS-ICUWLHSYSA-N

SMILES

[H]N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Soluble to 2mg/ml in water

Calculators

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

音量

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

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Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 14 publications citing the usage of this product.

Macrez A βγ dimer derived from G₁₃ transduces the angiotensin AT₁ receptor signal to stimulation of Ca²⁺ channels in rat portal vein myocytes. J.Biol.Chem. 1997 PMID: 9287322
Dang Two distinct mechanisms mediate acute μ-opioid receptor desensitization in native neurons. J.Neurosci. 2009 PMID: 19279269
Koch Cellular expression of the carboxyl terminus of a G protein-coupled receptor kinase attenuates G_βγ-mediated signaling. J.Biol.Chem. 1994 PMID: 8119963

Product Documents for GRK2i

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Download SDS

Product Specific Notices for GRK2i

For research use only

Citations for GRK2i

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