GSA 10

Key Product Details

Product Description

GSA 10 is a smoothened (Smo) receptor agonist (EC₅₀ = 1.2 μM). Does not recognize the classic cyclopamine (Cat. No. 1623) binding site. Does not promote Smo translocation to the primary cilium; is strongly potentiated by forskolin and cholera toxin. Displays anti-adipogenic effects in vitro, mediated by a non-canonical Hedgehog signaling pathway. Promotes differentiation of multipotent mesenchymal progenitor cells into osteoblasts.

Product Specifications for GSA 10

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for GSA 10

The following data is based on the product molecular weight 450.53.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.05 mM	44.39 mL	221.96 mL	443.92 mL
0.25 mM	8.88 mL	44.39 mL	88.78 mL
0.5 mM	4.44 mL	22.20 mL	44.39 mL
2.5 mM	0.89 mL	4.44 mL	8.88 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Fleury Hedgehog associated to microparticles inhibits adipocyte differentiation via a non-canonical pathway. Sci.Rep. 2016 PMID: 27010359
• Gorojankina Discovery, molecular and pharmacological characterization of GSA-10, a novel small-molecule positive modulator of Smoothened. Mol.Pharmacol. 2013 PMID: 23448715

Product Documents for GSA 10