GSK 5959

Tocris Bioscience | Catalog # 5385

Potent and selective BRPF1 inhibitor
Tocris Bioscience
Discontinued Product
5385 has been discontinued. View all Bromodomain Inhibitors products.

Key Product Details

Description

Potent and selective BRPF1 inhibitor
View all Bromodomain Inhibitors »

Product Description

GSK 5959 is a potent and selective BRPF1 bromodomain inhibitor (IC50 = 80 nM). Exhibits >100-fold selectivity for BRPF1 over a panel of 35 other bromodomains, including BRPF2/3 and BET family bromodomains. Inhibits BRPF1 interaction with histone H3.3. Cell permeable.

External Portal Information

Chemicalprobes.org

is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of GSK 5959 is reviewed on the chemical probes website.

Product Specifications for GSK 5959

Molecular Weight

394.47

Formula

C22H26N4O3

Storage

Store at +4°C

Purity

≥99% (HPLC)

Chemical Name

N-[2,3-Dihydro-1,3-dimethyl-2-oxo-6-(1-piperidinyl)-1H-benzimidazol-5-yl]-2-methoxybenzamide

CAS Number

901245-65-6

PubChem ID

15990224

InChI Key

LTUGYAOMCKNTGG-UHFFFAOYSA-N

SMILES

CN(C1=CC(NC(C4=C(OC)C=CC=C4)=O)=C(N3CCCCC3)C=C1N2C)C2=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 3.94 10 with sonication

Preparing Stock Solutions for GSK 5959

The following data is based on the product molecular weight 394.47.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 25.35 mL 126.75 mL 253.50 mL
0.5 mM 5.07 mL 25.35 mL 50.70 mL
1 mM 2.54 mL 12.68 mL 25.35 mL
5 mM 0.51 mL 2.54 mL 5.07 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 3 publications citing the usage of this product.

Product Documents for GSK 5959

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for GSK 5959

For research use only

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