GSK 789472 hydrochloride

Key Product Details

Product Description

Selective dopamine D₃ receptor antagonist and D₂ partial agonist (pEC₅₀ values are <5.5 and 8.3 respectively). Selective against the D₄ receptor in both agonist and antagonist assays. Brain penetrant.

Product Specifications for GSK 789472 hydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for GSK 789472 hydrochloride

The following data is based on the product molecular weight 295.81.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.38 mL	16.90 mL	33.81 mL
5 mM	0.68 mL	3.38 mL	6.76 mL
10 mM	0.34 mL	1.69 mL	3.38 mL
50 mM	0.07 mL	0.34 mL	0.68 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Holmes The identification of a selective DA D₂ partial agonist, D₃ antagonist displaying high levels of brain exposure. Bioorg.Med.Chem.Lett. 2010 PMID: 20153647

Product Documents for GSK 789472 hydrochloride