GT 949

Key Product Details

Product Description

GT 949 is a potent and selective EAAT2 positive allosteric modulator (EC₅₀ = 0.26 nM). Enhances the glutamate translocation rate, with no effect on substrate interaction. Enhances glutamate uptake by cultured astrocytes by approximately 58%. Exhibits no significant effect on DAT, SERT and NET or NMDA receptors. Neuroprotective in an in vitro model of excitotoxicity.

Product Specifications for GT 949

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for GT 949

The following data is based on the product molecular weight 527.66.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.90 mL	9.48 mL	18.95 mL
5 mM	0.38 mL	1.90 mL	3.79 mL
10 mM	0.19 mL	0.95 mL	1.90 mL
50 mM	0.04 mL	0.19 mL	0.38 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 3 publications citing the usage of this product.

• Falcucci Novel Positive Allosteric Modulators of Glutamate Transport Have Neuroprotective Properties in an in Vitro Excitotoxic Model. ACS Chem.Neurosci. 2019 PMID: 31257852
• Kortagere Identification of novel allosteric modulators of glutamate transporter EAAT2. ACS Chem.Neurosci. 2018 PMID: 29140675

Product Documents for GT 949