GW 4869

Tocris Bioscience | Catalog # 6741

Selective neutral sphingomyelin phosphodiesterase (N-SMase) inhibitor
Tocris Bioscience

Key Product Details

Description

Selective neutral sphingomyelin phosphodiesterase (N-SMase) inhibitor
View all Hydrolase Inhibitors »

Product Description

GW 4869 is a selective neutral sphingomyelin phosphodiesterase (N-SMase) inhibitor (IC50 = 1 μM). Exhibits selectivity for neutral sphingomyelinase over acid sphingomyelinase (a-SMase) at concentrations up to 150 μM as well as B. cereus PC-PLC, human lyso-PAF PLC, and bovine PP2A at 10 μM. Blocks exosome biogenesis. Inhibits TNF-α-induced sphingomyelin hydrolysis and TNF-α-induced cell death in MCF-7 cells. Reverses hypoxia-induced pulmonary vasoconstriction in rats. Neuroprotective.

Product Specifications for GW 4869

Molecular Weight

732.64

Formula

C30H28N6O2.2CF3COOH

Storage

Store at -20°C

Purity

≥90% (HPLC)

Chemical Name

3,3'-(1,4-Phenylene)bis[N-[4-(4,5-dihydro-1H-imidazol-2-yl)phenyl]-2-propenamide] ditrifluoroacetate

InChI Key

OVUGNZQTDFNYTB-CLEIDKRQSA-N

SMILES

O=C(/C=C/C1=CC=C(C=C1)/C=C/C(NC2=CC=C(C3=NCCN3)C=C2)=O)NC4=CC=C(C5=NCCN5)C=C4.OC(C(F)(F)F)=O.OC(C(F)(F)F)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 1.47 2

Preparing Stock Solutions for GW 4869

The following data is based on the product molecular weight 732.64.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.02 mM 68.25 mL 341.23 mL 682.46 mL
0.1 mM 13.65 mL 68.25 mL 136.49 mL
0.2 mM 6.82 mL 34.12 mL 68.25 mL
1 mM 1.36 mL 6.82 mL 13.65 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 14 publications citing the usage of this product.

Product Documents for GW 4869

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for GW 4869

For research use only

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