GW 7647

Tocris Bioscience | Catalog # 1677

Highly selective, potent PPARα agonist. Orally active
Tocris Bioscience

Key Product Details

Description

Highly selective, potent PPARα agonist. Orally active
View all PPAR alpha Receptor Agonists »

Product Description

GW 7647 is a potent and highly selective PPARα agonist (EC50 values are 6, 1100 and 6200 nM for human PPARα, PPARγ and PPARδ receptors respectively). Modulates oleate metabolism and mitochondrial enzyme gene expression in mature myotubules in vitro. Has lipid-lowering effects following oral administration in vivo. Reduces NO production in macrophages; exhibits anti-inflammatory properties.

Licensing Information

Sold for research purposes under agreement from GlaxoSmithKline

Product Specifications for GW 7647

Molecular Weight

502.75

Formula

C29H46N2O3S

Storage

Store at RT

Purity

≥98% (HPLC)

Chemical Name

2-[[4-[2-[[(Cyclohexylamino)carbonyl](4-cyclohexylbutyl)amino]ethyl]phenyl]thio]-2-methylpropanoic acid

CAS Number

265129-71-3

PubChem ID

3392731

InChI Key

PKNYXWMTHFMHKD-UHFFFAOYSA-N

SMILES

CC(C)(SC1=CC=C(CCN(CCCCC2CCCCC2)C(=O)NC2CCCCC2)C=C1)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 50.27 100
Ethanol 12.57 25

Preparing Stock Solutions for GW 7647

The following data is based on the product molecular weight 502.75.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.99 mL 9.95 mL 19.89 mL
5 mM 0.40 mL 1.99 mL 3.98 mL
10 mM 0.20 mL 0.99 mL 1.99 mL
50 mM 0.04 mL 0.20 mL 0.40 mL

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 47 publications citing the usage of this product.

Product Documents for GW 7647

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for GW 7647

For research use only

Customer Reviews for GW 7647 (1)

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  • PPAR alpha agonists inhibit nitric oxide production by enhancing iNOS degradation in LPS-treated macrophages.
    Name: GAJANAN KATKAR
    Species: Mouse
    Assay Type: In Vitro
    Cell Line/Tissue: J774 murine macrophages
    Verified Customer | Posted 12/07/2019
    GW7647 is the most potent PPARalpha agonist that reduces LPS-induced iNOS expression and NO production in macrophages by enhancing iNOS protein degradation through the proteasome pathway. Concentration 3, 10 and 30 uM showed dose-dependent inhibition.

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