GW 803430

Key Product Details

Product Description

GW 803430 is a selective melanin-concentrating hormone receptor 1 (MCH₁) antagonist (IC₅₀ = 9.3 nM). Displays antiobesity and antidepressant-like effects in rats and mice. Orally active.

Licensing Information

Sold for research purposes under agreement from GlaxoSmithKline.

Product Specifications for GW 803430

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for GW 803430

The following data is based on the product molecular weight 481.99.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.25 mM	8.30 mL	41.49 mL	82.99 mL
1.25 mM	1.66 mL	8.30 mL	16.60 mL
2.5 mM	0.83 mL	4.15 mL	8.30 mL
12.5 mM	0.17 mL	0.83 mL	1.66 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Gehlert Preclinical evaluation of melanin-concentrating hormone receptor 1 antagonism for the treatment of obesity and depression. J.Pharmacol.Exp.Ther. 2009 PMID: 19182070
• Rivera Melanin-concentrating hormone receptor 1 antagonists: a new perspective for the pharmacologic treatment of obesity. Curr.Med.Chem. 2008 PMID: 18393860

Product Documents for GW 803430