H 151

Key Product Details

Product Description

H 151 is a STING antagonist. Covalently binds STING at Cys91, blocking palmitoylation and preventing assembly of STING clusters. Decreases inflammatory cytokine production in human and mouse cells in vitro. Also blocks CMA (Cat. No. 6677) -induced increases in levels of inflammatory cytokines in mice, and alleviates systemic inflammation in a mouse model of autoinflammatory disease.

Product Specifications for H 151

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for H 151

The following data is based on the product molecular weight 279.34.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.58 mL	17.90 mL	35.80 mL
5 mM	0.72 mL	3.58 mL	7.16 mL
10 mM	0.36 mL	1.79 mL	3.58 mL
50 mM	0.07 mL	0.36 mL	0.72 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 15 publications citing the usage of this product.

• Haag Targeting STING with covalent small-molecule inhibitors. Nature 2018 PMID: 29973723

Product Documents for H 151