H10

Key Product Details

Product Description

H10 is a PARP14 inhibitor (IC₅₀ = 490 nM). Exhibits ~ 24- and 18-fold selectivity for PARP14 over PARP1 and TNKS1, respectively. Binds both the nicotinamide and adenine sites on PARP14. Inhibits PARP14 and induces apoptosis in HepG2 and RPMI-8226 in cancer cells in vitro.

Product Specifications for H10

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for H10

The following data is based on the product molecular weight 557.58.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	3.59 mL	17.93 mL	35.87 mL
2.5 mM	0.72 mL	3.59 mL	7.17 mL
5 mM	0.36 mL	1.79 mL	3.59 mL
25 mM	0.07 mL	0.36 mL	0.72 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Peng Small molecule microarray based discovery of PARP14 inhibitors. Angew.Chem.Int.Ed.Engl. 2017 PMID: 27918638

Product Documents for H10