H2L 5765834

Tocris Bioscience | Catalog # 4870

LPA1,3,5 antagonist
Tocris Bioscience
Discontinued Product
4870 has been discontinued. View all Lysophosphatidic Acid (LPA) Receptor Antagonists products.

Key Product Details

Description

LPA1,3,5 antagonist
View all Lysophosphatidic Acid (LPA) Receptor Antagonists »

Product Description

H2L 5765834 is an antagonist of the lysophosphatidic acid receptors LPA1, LPA5 and LPA3 (IC50 values are 94, 463 and 752 nM respectively). Exhibits no effect at LPA2 or LPA4 receptors.

Product Specifications for H2L 5765834

Molecular Weight

404.33

Formula

C21H12N2O7

Storage

Store at +4°C

Purity

≥99% (HPLC)

Chemical Name

2,3-Dihydro-2-[3-(4-nitrophenoxy)phenyl]-1,3-dioxo-1H-isoindole-5-carboxylic acid

CAS Number

420841-84-5

PubChem ID

1365686

InChI Key

HFYPTENHTPNXGP-UHFFFAOYSA-N

SMILES

O=C2N(C3=CC=CC(OC4=CC=C([N+]([O-])=O)C=C4)=C3)C(C1=CC(C(O)=O)=CC=C12)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 40.43 100

Preparing Stock Solutions for H2L 5765834

The following data is based on the product molecular weight 404.33.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.47 mL 12.37 mL 24.73 mL
5 mM 0.49 mL 2.47 mL 4.95 mL
10 mM 0.25 mL 1.24 mL 2.47 mL
50 mM 0.05 mL 0.25 mL 0.49 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 7 publications citing the usage of this product.

Product Documents for H2L 5765834

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for H2L 5765834

For research use only

Customer Reviews for H2L 5765834 (1)

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  • H2L 5765834 inhibits LPA induced COX-2 expression in osteosarcoma cells
    Name: Christopher Trummer
    Species: Human
    Assay Type: In Vitro
    Cell Line/Tissue: Osteosarcoma
    Verified Customer | Posted 10/23/2018
    MG-63 cells were treated with LPA (10 µM) alone or in combination with C3 (20 µM), PTX (Pertussis Toxin, 400 ng/ml) or H2L 5765834 (20 µM) for 3 h to follow COX-2 expression using Western blot. H2L inhibited COX-2 expression induced by LPA.
    H2L 5765834 4870

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