Haloperidol hydrochloride

Tocris Bioscience | Catalog # 0931

Dopamine antagonist; displays some D2 selectivity
Tocris Bioscience

Key Product Details

Description

Dopamine antagonist; displays some D2 selectivity
View all Non-selective Dopamine Receptor Antagonists »

Product Description

Haloperidol hydrochloride is a dopamine antagonist with selectivity for D2-like receptors (Ki values are 1.2, ~ 7, 2.3, ~ 80 and ~ 100 nM for D2, D3, D4, D1 and D5 receptors respectively). Subtype-selective NMDA antagonist. Identified as targeting human host proteins that interact with SARS-CoV-2.

Product Specifications for Haloperidol hydrochloride

Molecular Weight

412.33

Formula

C21H23ClFNO2.HCl

Storage

Store at RT

Purity

≥98% (HPLC)

Chemical Name

4-[4-(4-Chlorophenyl)-4-hydroxy-1-piperidinyl]-1-(4-fluorophenyl)-1-butanone hydrochloride

CAS Number

1511-16-6

PubChem ID

11495267

InChI Key

JMRYYMBDXNZQMH-UHFFFAOYSA-N

SMILES

Cl.OC1(CCN(CCCC(=O)C2=CC=C(F)C=C2)CC1)C1=CC=C(Cl)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 10.31 25 with gentle warming

Preparing Stock Solutions for Haloperidol hydrochloride

The following data is based on the product molecular weight 412.33.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.25 mM 9.70 mL 48.50 mL 97.01 mL
1.25 mM 1.94 mL 9.70 mL 19.40 mL
2.5 mM 0.97 mL 4.85 mL 9.70 mL
12.5 mM 0.19 mL 0.97 mL 1.94 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 38 publications citing the usage of this product.

Product Documents for Haloperidol hydrochloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Haloperidol hydrochloride

For research use only

⚠ WARNING: This product can expose you to chemicals including Haloperidol, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov

Citations for Haloperidol hydrochloride

Customer Reviews for Haloperidol hydrochloride (1)

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  • Antagonist of D2R
    Name: Luiz Alexandre Magno
    Species: Rat
    Assay Type: In Vitro
    Cell Line/Tissue: PC12 cells
    Verified Customer | Posted 10/26/2018
    I used haloperidol hydrochloride to block D2 dopamine receptors, which increases phosphorylation of the Akt protein (see the western blot image).
    Haloperidol hydrochloride 0931

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