HC 030031

Tocris Bioscience | Catalog # 2896

Selective TRPA1 blocker
Tocris Bioscience

Key Product Details

Description

Selective TRPA1 blocker
View all TRPA1 Blockers »

Product Description

HC 030031 is a selective TRPA1 channel blocker that antagonizes AITC- and formalin-evoked calcium influx (IC50 values are 6.2 and 5.3 μM respectively). Does not block currents mediated by TRPV1, TRPV3, TRPV4, hERG or NaV1.2 channels. Inhibits AITC- and formalin-induced flinching in vivo.

Product Specifications for HC 030031

Molecular Weight

355.39

Formula

C18H21N5O3

Storage

Store at RT

Purity

≥98% (HPLC)

Chemical Name

2-(1,3-Dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide

CAS Number

349085-38-7

PubChem ID

1150897

InChI Key

HEQDZPHDVAOBLN-UHFFFAOYSA-N

SMILES

O=C1C2=C(N=CN2CC(NC3=CC=C(C(C)C)C=C3)=O)N(C)C(N1C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 35.54 100

Preparing Stock Solutions for HC 030031

The following data is based on the product molecular weight 355.39.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.81 mL 14.07 mL 28.14 mL
5 mM 0.56 mL 2.81 mL 5.63 mL
10 mM 0.28 mL 1.41 mL 2.81 mL
50 mM 0.06 mL 0.28 mL 0.56 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 118 publications citing the usage of this product.

Product Documents for HC 030031

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for HC 030031

For research use only

Related Research Areas

Ion Channels and Regulators

Customer Reviews for HC 030031 (2)

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  • breast cancer cell viability by a cannabinoid receptor 2 agonist
    Name: Anonymous
    Species: Human
    Assay Type: In Vitro
    Cell Line/Tissue: MCF-7
    Verified Customer | Posted 03/15/2020
    We used all these compounds which were dissolved in DMSO and added to fresh culture media. Concentration reference paper PMID: 27186076
    HC 030031 2896
  • blocking dTRPA1 in fruit fly embryos
    Name: Ginger Hunter
    Species: Drosophila melanogaster
    Assay Type: In Vivo
    Verified Customer | Posted 01/04/2018
    microinjection of the TRPA1 inhibitor HC 030031 into Drosophila melanogaster embryos. Drug appears to phenocopy aspects of the null mutant and RNAi knockdown of the TRPA1 gene in embryos fairly well.
    HC 030031 2896

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