hCAII Degrader 11

Key Product Details

Product Description

hCAII Degrader 11 is a potent human carbonic anhydrase II (hCAII) Degrader (PROTAC^®; D_max = 100% at 5 nM, DC₅₀ = 0.5 nM).

PROTAC^® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Sold with kind permission of Professor Cohen and Professor Burkart, Department of Chemistry and Biochemistry, University of California, USA.

Licensing Information

Sold with kind permission of Professor Cohen and Professor Burkart

Product Specifications for hCAII Degrader 11

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for hCAII Degrader 11

The following data is based on the product molecular weight 639.77.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.56 mL	7.82 mL	15.63 mL
5 mM	0.31 mL	1.56 mL	3.13 mL
10 mM	0.16 mL	0.78 mL	1.56 mL
50 mM	0.03 mL	0.16 mL	0.31 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• O'Herin Development of human carbonic anhydrase II heterobifunctional degraders J.Med.Chem. 2023 PMID: 36735827

Product Documents for hCAII Degrader 11