Hemopressin (rat)

Name: Hemopressin (rat)
Brand: Tocris Bioscience
SKU: 1764
Price: 263 USD

Catalog #: 1764 Datasheet / COA / SDS

Discontinued Product

1764 has been discontinued.

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Description: Selective CB1 inverse agonist

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Product Details

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Biological Activity

Hemopressin (rat) is a bioactive endogenous peptide substrate for endopeptidase 24.15 (ep24.15), neurolysin (ep24.16) and ACE. K_i values are 27.76, 3.43 and 1.87 μM respectively. Potent hypotensive in vivo. Also acts as a selective CB₁ receptor inverse agonist. Displays antinociceptive activity and induces hypophagia in vivo.

Technical Data

M.Wt:

1088.27

Formula:

C₅₃H₇₇N₁₃O₁₂

Sequence:

PVNFKFLSH

Solubility:

Soluble to 2 mg/ml in 20% acetonitrile

Storage:

Desiccate at -20°C

CAS No:

568588-77-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

Novel natural peptide substrates for endopeptidase 24.15, neurolysin, and angiotensin-converting enzyme.
Rioli et al.
J.Biol.Chem., 2003;278:8547
Hemopressin is an inverse agonist of CB₁ cannabinoid receptors.
Heimann et al.
Proc.Natl.Acad.Sci.U.S.A., 2007;104:20588
The peptide hemopressin acts through CB₁ cannabinoid receptors to reduce food intake in rats and mice.
Todd et al.
J.Neurosci., 2010;30:7369

Product Datasheets

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

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