HER2 PROTAC® CH7C4

Tocris Bioscience | Catalog # 7886

Potent and selective HER2 targeting Degrader (PROTAC®)
Tocris Bioscience

Key Product Details

Description

Potent and selective HER2 targeting Degrader (PROTAC®)
View all Active Degraders »

Product Description

HER2 PROTAC® CH7C4 is a potent and selective HER2 (also called ErbB-2) targeting Degrader (PROTAC®) (DC50 = 69 nM; Dmax = 96%). Inhibits BT-474 cell proliferation (IC50 = 47 nM) and xenograft growth. Comprises a Tucatinib (Cat. No. 7640) analog, joined by a linker to a CRBN E3 ligase ligand.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Product Specifications for HER2 PROTAC® CH7C4

Molecular Weight

910.05

Formula

C49H55N11O7

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

5-((7-(4-(3-((4-((4-([1,2,4]Triazolo[1,5-a]pyridin-7-yloxy)-3-methylphenyl)amino)-6-methoxyquinazolin-7-yl)oxy)propyl)piperazin-1-yl)heptyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione

CAS Number

2897640-93-4

InChI Key

IQCKLHMMRZVWLF-UHFFFAOYSA-N

SMILES

CC1=C(C=CC(NC2=NC=NC3=CC(OCCCN4CCN(CC4)CCCCCCCNC5=CC(C(N6C7CCC(NC7=O)=O)=O)=C(C=C5)C6=O)=C(C=C32)OC)=C1)OC8=CC9=NC=NN9C=C8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 91 100

Preparing Stock Solutions for HER2 PROTAC® CH7C4

The following data is based on the product molecular weight 910.05.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.10 mL 5.49 mL 10.99 mL
5 mM 0.22 mL 1.10 mL 2.20 mL
10 mM 0.11 mL 0.55 mL 1.10 mL
50 mM 0.02 mL 0.11 mL 0.22 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for HER2 PROTAC® CH7C4

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for HER2 PROTAC® CH7C4

For research use only

Citations for HER2 PROTAC® CH7C4

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