HI TOPK 032

Key Product Details

Product Description

HI TOPK 032 is a T-LAK-cell-originated protein kinase (TOPK) inhibitor; exhibits selectivity for TOPK over other MAPKK family members including ERK1, JNK1 and p38. Blocks proliferation of HCT116 colon cancer cells; suppresses tumor growth in a colon cancer xenograft model. Also inhibits Chk1 (IC₅₀ = 9.6 μM).

Product Specifications for HI TOPK 032

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for HI TOPK 032

The following data is based on the product molecular weight 369.40.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	13.54 mL	67.68 mL	135.35 mL
1 mM	2.71 mL	13.54 mL	27.07 mL
2 mM	1.35 mL	6.77 mL	13.54 mL
10 mM	0.27 mL	1.35 mL	2.71 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Kim Novel TOPK inhibitor HI-TOPK-032 effectively suppresses colon cancer growth. Cancer Res. 2012 PMID: 22523035
• Li Discovery of novel checkpoint kinase 1 inhibitors by virtual screening based on multiple crystal structures. J.Chem.Inf.Model. 2011 PMID: 21955044

Product Documents for HI TOPK 032