HIOC

Key Product Details

Product Description

HIOC is a selective TrkB receptor agonist. Protects neurons from excitotoxicity. Protects retinas from light-induced retinal degeneration (LIRD) in vivo. Blood brain barrier and blood-retinal barrier penetrant.

Product Specifications for HIOC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for HIOC

The following data is based on the product molecular weight 301.34.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.32 mL	16.59 mL	33.19 mL
5 mM	0.66 mL	3.32 mL	6.64 mL
10 mM	0.33 mL	1.66 mL	3.32 mL
50 mM	0.07 mL	0.33 mL	0.66 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Shen N-acetyl serotonin derivatives as potent neuroprotectants for retinas Proc.Natl.Acad.Sci.USA 2012 PMID: 22331903
• Setterholm Gram-scale, chemoselective synthesis of N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]-2-oxopiperidine-3-carboxamide (HIOC) Tetrahedron Lett. 2015 PMID: 26028783

Product Documents for HIOC