Chemical Name: N-[2-(5-Hydroxy-1H-indol-3-yl)ethyl]-2-oxo-3-piperidinecarboxamide
Biological ActivityHIOC is a selective TrkB receptor agonist. Protects neurons from excitotoxicity. Protects retinas from light-induced retinal degeneration (LIRD) in vivo. Blood brain barrier and blood-retinal barrier penetrant.
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For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Gram-scale, chemoselective synthesis of N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]-2-oxopiperidine-3-carboxamide (HIOC)
Setterholm et al.
Tetrahedron Lett., 2015;56:3413
N-acetyl serotonin derivatives as potent neuroprotectants for retinas
Shen et al.
Citation for HIOC
The citations listed below are publications that use Tocris products. Selected citations for HIOC include:
1 Citation: Showing 1 - 1
Minocycline promotes posthemorrhagic neurogenesis via M2 microglia polarization via upregulation of the TrkB/BDNF pathway in rats.
Authors: Hang Et al.
J Neurophysiol 2018;120:1307-1317
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