HS 014

Tocris Bioscience | Catalog # 1831

Selective MC4 receptor antagonist
Tocris Bioscience

Key Product Details

Description

Selective MC4 receptor antagonist
View all Melanocortin Receptor Antagonists »

Product Description

HS 014 is a potent and selective melanocortin MC4 receptor antagonist (Ki values are 3.16, 108, 54.4 and 694 nM for cloned human MC4, MC1, MC3 and MC5 receptors respectively). Increases food intake in rats and nociception in mice following central administration in vivo. Also inhibits IL-1β-induced Fos expression in the paraventricular hypothalamus.

Product Specifications for HS 014

Molecular Weight

1563.77

Formula

C71H94N20O17S2

Storage

Store at -20°C

Purity

≥95% (HPLC)

CAS Number

207678-81-7

PubChem ID

24821295

InChI Key

BRGDPINZISNYJL-VMAVSDBDSA-N

SMILES

CC(=O)N[C@H]1CSSC[C@H](NC(=O)CNC(=O)[C@H](CC2=CNC3=C2C=CC=C3)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](CC2=CC3=CC=CC=C3C=C2)NC(=O)[C@H](CC2=CNC=N2)NC(=O)[C@H](CCC(O)=O)NC1=O)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(O)=O)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solubility Soluble to 1mg/ml in water

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 13 publications citing the usage of this product.

Product Documents for HS 014

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for HS 014

For research use only

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