HS 014

Tocris Bioscience | Catalog # 1831

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Citations (13)

Product Documents

Selective MC4 receptor antagonist

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Product Description
Product Specifications
Solubility
Calculators
Background References
Product Documents
Specific Notices
Research Areas

Key Product Details

Description

Selective MC4 receptor antagonist

View all Melanocortin Receptor Antagonists »

Product Description

HS 014 is a potent and selective melanocortin MC₄ receptor antagonist (K_i values are 3.16, 108, 54.4 and 694 nM for cloned human MC₄, MC₁, MC₃ and MC₅ receptors respectively). Increases food intake in rats and nociception in mice following central administration in vivo. Also inhibits IL-1β-induced Fos expression in the paraventricular hypothalamus.

Product Specifications for HS 014

Molecular Weight

1563.77

Formula

C₇₁H₉₄N₂₀O₁₇S₂

Storage

Store at -20°C

Purity

≥95% (HPLC)

CAS Number

207678-81-7

PubChem ID

24821295

InChI Key

BRGDPINZISNYJL-VMAVSDBDSA-N

SMILES

CC(=O)N[C@H]1CSSC[C@H](NC(=O)CNC(=O)[C@H](CC2=CNC3=C2C=CC=C3)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](CC2=CC3=CC=CC=C3C=C2)NC(=O)[C@H](CC2=CNC=N2)NC(=O)[C@H](CCC(O)=O)NC1=O)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(O)=O)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Soluble to 1mg/ml in water

Calculators

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音量

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 13 publications citing the usage of this product.

Schioth Discovery of novel melanocortin₄ receptor selective MSH analogues. Br.J.Pharmacol. 1998 PMID: 9630346
Whitaker and Reye Central blockade of melanocortin receptors attenuates the metabolic and locomotor responses to peripheral interleukin-1β administration. Neuropharmacology 2008 PMID: 18082228
Bellasio Melanocortin receptor agonists and antagonists modulate nociceptive sensitivity in the mouse formalin test. Eur.J.Pharmacol. 2003 PMID: 14660013

Product Documents for HS 014

Certificate of Analysis

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Download SDS

Product Specific Notices for HS 014

For research use only

Related Research Areas

Metabolic Peptide Hormones and Regulators

Nutrition and Appetite

Citations for HS 014

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