Human APLP-2 Alexa Fluor® 750-conjugated Antibody

Catalog #: FAB49451S Datasheet / COA / SDS

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FAB49451S-100UG

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Human APLP-2 Alexa Fluor® 750-conjugated Antibody Summary

Species Reactivity

Human

Specificity

Detects human APLP-2 in direct ELISAs and Western blots. In direct ELISAs, no cross-reactivity with recombinant mouse APLP-2 or recombinant human APLP-1 is observed.

Source

Monoclonal Mouse IgG2b Clone # 397702

Purification

Protein A or G purified

Immunogen

Mouse myeloma cell line NS0-derived recombinant human APLP-2
Leu30-Ser680
Accession # Q06481

Formulation

Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Label

Alexa Fluor 750 (Excitation= 749 nm, Emission= 775 nm)

Applications

Recommended Concentration

Sample

Western Blot

Optimal dilution of this antibody should be experimentally determined.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

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Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: APLP-2

Amyloid beta precursor-like protein 2 (APLP-2) is a 120-170 kDa member of the APP family of neuronal type I transmembrane proteins. Its extracellular domain consists of an N-terminal Cys-rich domain, an Asp/Glu-rich acidic region, a Kunitz protease inhibitor (KPI) domain, and a GAG attachment site in the membrane proximal domain. APLP-2 forms both homodimers and heterodimers with APP and APLP-1. Proteolytic cleavage of APLP-2 generates peptides similar to the amyloidogenic A beta peptides and a cytoplasmic fragment that functions as a transcriptional coactivator. Alternate splicing of APLP-2 generates isoforms that lack the KPI domain or contain an insertion that prevents GAG attachment. The extracellular domain of human APLP-2 shares 81% and 93% aa sequence identity with mouse and rat APLP-2, respectively.

Long Name

Amyloid Beta [A4] Precursor-like Protein 2

Entrez Gene IDs

334 (Human); 11804 (Mouse); 64312 (Rat)

Alternate Names

amyloid beta (A4) precursor-like protein 2; amyloid precursor protein homolog HSD-2; Amyloid protein homolog; amyloid-like protein 2; APLP2; APLP-2; APPH; APPHCDEI box-binding protein; APPL2; CDEBP; WALPLP2; YWK-II