Human CD3 zeta/CD247 (NP_932170) VersaClone cDNA

Name: Human CD3 zeta/CD247 (NP_932170) VersaClone cDNA
Brand: R&D Systems
SKU: RDC1744
Price: 270 USD
Availability: InStock

R&D Systems | Catalog # RDC1744

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Background
Product Documents
Specific Notices
Research Areas

Key Product Details

Species

Human

Accession Number

NP_932170

Background: CD3 zeta/CD247

CD3 (Cluster of Differentiation 3) is a complex of proteins that associates directly with the T cell antigen receptor (TCR). Antigen binding to the TCR leads to IL-2 secretion via activation of a tyrosine phosphorylation pathway and a phospholipase C (PLC) pathway, in turn activating protein kinase C. CD3 is composed of five invariant polypeptide chains that associate to form three dimers. The five invariant chains of CD3 are labeled gamma, delta, epsilon, zeta, and eta. The zeta chain plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. Loss of the zeta chain results in the synthesis of unstable TCRs. A decrease of CD3 zeta has been described in T cells from patients with cancer, lupus and chronic infectious diseases.

Long Name

T-cell Receptor zeta

Alternate Names

CD247, CD3H, CD3Q, CD3Z, IMD25, T3Z, TCR Zeta Chain

Entrez Gene IDs

919 (Human); 12503 (Mouse); 25300 (Rat)

Gene Symbol

CD247

UniProt

NP_932170

Additional CD3 zeta/CD247 Products

Product Documents for Human CD3 zeta/CD247 (NP_932170) VersaClone cDNA

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Product Specific Notices for Human CD3 zeta/CD247 (NP_932170) VersaClone cDNA

For research use only

Related Research Areas

ITIM/ITAM Immunoreceptors and Related Molecules

Regulatory T Cells (Tregs)

T Cell Antigen Recognition

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