Human Connexin 26/GJB2 (NP_003995) VersaClone cDNA

Name: Human Connexin 26/GJB2 (NP_003995) VersaClone cDNA
Brand: R&D Systems
SKU: RDC1027
Price: 270 USD
Availability: InStock

R&D Systems | Catalog # RDC1027

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Background
Product Documents
Specific Notices
Research Areas

Key Product Details

Species

Human

Accession Number

NP_003995

Background: Connexin 26/GJB2

Connexin-26 / GJB2 is a gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexins, through which materials of low molecular weight diffuse from one cell to a neighboring cell. Each connexin is composed of a hexamer of connexin proteins. Connexins are a multi-gene family of highly related proteins. At least a dozen distinct connexin genes have been identified and many are expressed in a tissue-specific manner. Two distinct lineages, class I (beta) and class II (alpha), have been identified in mammals. Connexin-26 belongs to the class 1 (beta) group of connexins. Mutations in Connexin-26 are associated with genetically derived hearing impairments, including autosomal recessive non syndromic deafness.

Alternate Names

CX26, DFNA3, DFNB1, GJB2, HID, KID, NSRD1, PPK

Entrez Gene IDs

2706 (Human); 14619 (Mouse); 394266 (Rat)

Gene Symbol

GJB2

UniProt

NP_003995

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Product Specific Notices for Human Connexin 26/GJB2 (NP_003995) VersaClone cDNA

For research use only

Related Research Areas

Ion Channels and Regulators

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