Human Dishevelled-2 Antibody (373413)

R&D Systems | Catalog # MAB4216

R&D Systems

Key Product Details

Species Reactivity

Validated:

Human

Cited:

Human

Applications

Validated:

Western Blot

Cited:

Western Blot

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG1 Clone # 373413
View all Dishevelled-2 Primary Antibodies »

Product Specifications

Immunogen

E. coli-derived recombinant human Dishevelled-2
Leu78-Thr250
Accession # O14641

Specificity

Detects human Dishevelled‑2 in direct ELISAs and Western blots. In direct ELISAs and Western blots, no cross-reactivity with recombinant human (rh) DVL-1 or rhDVL-3 is observed.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1

Applications for Human Dishevelled-2 Antibody (373413)

Application
Recommended Usage

Western Blot

1 µg/mL
Sample: Recombinant Human Dishevelled‑2

Formulation, Preparation, and Storage

Purification

Protein A or G purified from hybridoma culture supernatant

Reconstitution

Reconstitute at 0.5 mg/mL in sterile PBS. For liquid material, refer to CoA for concentration.

Formulation

Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.

Shipping

Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.

Stability & Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Calculators

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Background: Dishevelled-2

Dishevelled-2 (DVL-2) is a 90‑95 kDa cytoplasmic phosphoprotein that is one of the three Drosophila dishevelled orthologs. Human DVL-2 is expressed in multiple tissues, participates in Wnt signal transduction and may mediate Wnt-dependent motility. DVL-2 is a modular protein containing DIX, PDZ and DEP linker regions that connect Wnt/Frizzled engagement to proteins involved in the inactivation of beta -catenin destruction in the Wnt canonical pathway. Human and mouse DVL-2 share 94% aa identity over the sequence used for immunization.

Alternate Names

Dishevelled2, DVL2

Entrez Gene IDs

1856 (Human); 13543 (Mouse); 303251 (Rat)

Gene Symbol

DVL2

UniProt

O14641

Additional Dishevelled-2 Products

Product Documents for Human Dishevelled-2 Antibody (373413)

Certificate of Analysis

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Note: Certificate of Analysis not available for kit components.

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Product Specific Notices for Human Dishevelled-2 Antibody (373413)

For research use only

Related Research Areas

Wnt Family

Citations for Human Dishevelled-2 Antibody (373413)

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