Human DISP2 Alexa Fluor® 700-conjugated Antibody

Catalog #: FAB8434N Datasheet / COA / SDS

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FAB8434N-100UG

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Human DISP2 Alexa Fluor® 700-conjugated Antibody Summary

Species Reactivity

Human

Specificity

Detects human DISP2 in direct ELISAs.

Source

Monoclonal Mouse IgG2b Clone # 758204

Purification

Protein A or G purified

Immunogen

E. coli-derived recombinant human DISP2
Arg192-Lys477
Accession # A7MBM2

Formulation

Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Label

Alexa Fluor 700 (Excitation= 675-700 nm, Emission= 723 nm)

Applications

Recommended Concentration

Sample

Western Blot

Optimal dilution of this antibody should be experimentally determined.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: DISP2

DISP2 (Dispatched Homolog 2), also known as DISPB, belongs to the dispatched family of sterol-sensing proteins. DISP2 and the closely related DISP1 were initially identified in mice by their high homology with Dispatched, a protein required for long-range Hedgehog (Hh) signaling in Drosophila. Like DISP1, DISP2 is a multispan (12) transmembrane protein with both cytoplasmic N- and C-terminal tails. DISP2 contains a sterol-sensing domain (SSD) of 173 amino acids (aa), and may be involved in regulating the release of cholesterol-modified Sonic Hedgehog (Shh). Human DISP2 is 1401 aa in length, with three predicted N-linked glycosylation sites. Over aa 192-477, human DISP2 shares 72% and 73% aa identity with mouse and rat DISP2, respectively.

Long Name

Dispatched 2

Entrez Gene IDs

85455 (Human); 214240 (Mouse); 311324 (Rat)

Alternate Names

DISP2; Dispatched B; Dispatched Homolog 2 (Drosophila); DISPB; HsT16908; KIAA1742; Protein Dispatched Homolog 2