Human Fc gamma RIIB/C (CD32b/c) Alexa Fluor® 405-conjugated Antibody

Catalog #: FAB18751V Datasheet / COA / SDS

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FAB18751V-100UG

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Human Fc gamma RIIB/C (CD32b/c) Alexa Fluor® 405-conjugated Antibody Summary

Species Reactivity

Human

Specificity

Detects human Fc gamma RIIB/C in ELISAs. In a sandwich ELISA shows approximately 40% cross-reactivity with recombinant human (rh) Fc gamma RIIA and no cross‑reactivity with rhFc gamma RI, rmFc gamma RI, rmFc gamma RIIB, rhFc gamma RIIIB, rmFc gamma RIII, or rmFcrl3/CD16-2.

Source

Monoclonal Mouse IgG2b Clone # 190710

Purification

Protein A or G purified

Immunogen

Mouse myeloma cell line NS0-derived recombinant human FcÎ³ RIIB/C
Ala46-Pro217
Accession # P31994

Formulation

Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Label

Alexa Fluor 405 (Excitation= 405 nm, Emission= 421 nm)

Applications

Recommended Concentration

Sample

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

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Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: Fc gamma RIIC/CD32c

Fc gamma RII, also known as CD32, is a group of three closely related proteins (Fc gamma RIIA, Fc gamma RIIB, Fc gamma RIIC) that share greater than 94% amino acid identity in their extracellular domains with Fc gamma RIIB and Fc gamma RIIC having identical extracellular domains. They function as transmembrane receptors for the Fc portion of IgG molecules. These proteins are expressed by various hematopoietic cells including monocytes, macrophages, neutrophils, NK, T and B cells. The Fc gamma RII proteins are involved in phagocytosis of immune complexes and modulation of antibody production by B cells.

Long Name

Fc gamma Receptor II

Entrez Gene IDs

9103 (Human)

Alternate Names

low affinity immunoglobulin gamma Fc region receptor II-c; CD32; CD32c; CDW32; Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene); Fc gamma RIIC; FCG2; FCGR2C; FcgRIIC; FCRIIC; IGFR2