Human FoxC1 Alexa Fluor® 532-conjugated Antibody

Catalog #: FAB6329X Datasheet / COA / SDS

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FAB6329X-100UG

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All FoxC1 Antibodies

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Summary Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Human FoxC1 Alexa Fluor® 532-conjugated Antibody Summary

Species Reactivity

Human

Specificity

Detects human FoxC1 in direct ELISAs and Western blots.

Source

Monoclonal Mouse IgG1 Clone # 625905

Purification

Protein A or G purified

Immunogen

E. coli-derived recombinant human FoxC1
Gln208-Gln322
Accession # Q12948

Formulation

Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Label

Alexa Fluor 532 (Excitation= 534 nm, Emission= 553 nm)

Applications

Recommended Concentration

Sample

Western Blot

Optimal dilution of this antibody should be experimentally determined.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: FoxC1

Human FoxC1 (forkhead box C1), also called FKHL7 (forkhead-like 7) or FREAC3 (forkhead-related activator 3) is a 553 amino acid (aa) intracellular phosphoprotein that belongs to a large family of nuclear transcription factors that share a common forkhead/winged helix DNA binding domain. FoxC1 is essential for formation of mesodermal tissues; mutations underlie Axenfeld-Rieger malformations of the eye. The human FoxC1 sequence includes a DNA binding domain at aa 77‑168 and an inhibitory domain between aa 268‑245. Phosphorylation within this inhibitory region causes a protein gel mobility shift. Human FoxC1 shares 92% and 91% aa identity with mouse and rat FoxC1, respectively.

Long Name

Forkhead Box C1

Entrez Gene IDs

2296 (Human); 17300 (Mouse)

Alternate Names

ARA; FKHL7; FKHL7RIEG3; forkhead box C1; forkhead box protein C1; forkhead, drosophila, homolog-like 7; forkhead/winged helix-like transcription factor 7; forkhead-related activator 3; Forkhead-related protein FKHL7; Forkhead-related transcription factor 3; FoxC1; FREAC3; FREAC-3; FREAC3IRID1; IGDA; IHG1; IRID1; myeloid factor-delta; RIEG3