The high-affinity IFN-gamma receptor complex is made up of two type I membrane proteins, IFN-gamma R1 (IFN-gamma R alpha ) and IFN-gamma R2 (IFN-gamma R beta ). Both proteins are members of the type II cytokine receptor family and share approximately 52% amino acid sequence identity. IFN-gamma R1 is the ligand-binding subunit that is necessary and sufficient for IFN-gamma binding and receptor internalization. IFN-gamma R2 is required for IFN-gamma signaling but does not bind IFN-gamma by itself. Human IFN-gamma R1 cDNA encodes a 499 amino acid (aa) protein with a 17 aa signal peptide, a 228 aa extracellular domain, a 23 aa transmembrane domain, and a 221 aa intracellular domain. Human and mouse IFN-gamma R1 share 52% aa identity and bind IFN-gamma in a species-specific manner. IFN-gamma R1 is constitutively expressed in most cell types. Soluble IFN-gamma R1 that binds IFN-gamma has been detected in biological fluids.
Human IFN‑ gamma R1/CD119 Alexa Fluor™ Plus 555‑conjugated Antibody
R&D Systems | Catalog # FAB6732AFP555
Key Product Details
Species Reactivity
Applications
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Antibody Source
Product Specifications
Specificity
Clonality
Host
Isotype
Applications for Human IFN‑ gamma R1/CD119 Alexa Fluor™ Plus 555‑conjugated Antibody
Neutralization
Formulation, Preparation, and Storage
Formulation
Shipping
Stability & Storage
Background: IFN-gamma R1/CD119
References
- Bach, E.A. et al. (1997) Annu. Rev. Immunol. 15:563.
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Additional IFN-gamma R1/CD119 Products
Product Documents for Human IFN‑ gamma R1/CD119 Alexa Fluor™ Plus 555‑conjugated Antibody
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Product Specific Notices for Human IFN‑ gamma R1/CD119 Alexa Fluor™ Plus 555‑conjugated Antibody
This product is provided under an intellectual property license from Life Technologies Corporation. The transfer of this product is conditioned on the buyer using the purchased product solely in research conducted by the buyer, excluding contract research or any fee for service research, and the buyer must not (1) use this product or its components for (a) diagnostic, therapeutic or prophylactic purposes; (b) testing, analysis or screening services, or information in return for compensation on a per-test basis; or (c) manufacturing or quality assurance or quality control, and/or (2) sell or transfer this product or its components for resale, whether or not resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com.
For research use only
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