Human IL-38/IL-1F10 Alexa Fluor® 350-conjugated Antibody

Catalog #: FAB2427U Datasheet / COA / SDS

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FAB2427U-100UG

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Human IL-38/IL-1F10 Alexa Fluor® 350-conjugated Antibody Summary

Species Reactivity

Human

Specificity

Detects human IL‑38/IL‑1F10 in direct ELISAs and Western blots. In direct ELISAs and Western blots, approximately 50% cross-reactivity with recombinant mouse IL-1F10 is observed and no cross-reactivity with recombinant human (rh) IL-1 alpha /IL-1F1 rhIL-1 beta /IL-1

Source

Monoclonal Rat IgG2b Clone # 316709

Purification

Protein A or G purified

Immunogen

E. coli-derived recombinant human ILâ€‘38/ILâ€‘1F10
Met1-Trp152
Accession # Q8WWZ1

Formulation

Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Label

Alexa Fluor 350 (Excitation= 346 nm, Emission= 442 nm)

Applications

Recommended Concentration

Sample

Western Blot

Optimal dilution of this antibody should be experimentally determined.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

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Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: IL-38/IL-1F10

Human IL-38, previously called IL-1F10 or IL-1HY2, is a secreted cytokine belonging to the IL-1 family. It is synthesized as a 152 amino acid mature protein that lacks an identifiable signal sequence. It binds to soluble IL-1 RI. Human IL-38/IL-1F10 shares 82% aa sequence identity with mouse IL-38/IL-1F10. Human IL-38/IL-1F10 also shares 39% and 27% aa sequence identity with IL-1ra/IL-1F3 and IL-1 beta /IL-1F2, respectively.

Long Name

Interleukin 1 Family Member 10

Entrez Gene IDs

84639 (Human); 215274 (Mouse); 102125744 (Cynomolgus Monkey)

Alternate Names

FIL1- theta; FKSG75; IL1F10; IL-1HY2; IL38; IL-38; interleukin 1 family, member 10 (theta); UNQ6119/PRO20041