Human Kremen-1 Alexa Fluor® 750-conjugated Antibody

Catalog #: FAB2127S Datasheet / COA / SDS

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FAB2127S-100UG

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Human Kremen-1 Alexa Fluor® 750-conjugated Antibody Summary

Species Reactivity

Human

Specificity

Detects human Kremen-1 in direct ELISAs and Western blots. In direct ELISAs and Western blots, no cross‑reactivity with recombinant mouse Kremen-1 or recombinant human Kremen-2 is observed.

Source

Monoclonal Mouse IgG1 Clone # 301324

Purification

Protein A or G purified

Immunogen

Mouse myeloma cell line NS0-derived recombinant human Kremenâ€‘1
Ala20-Gly397
Accession # NP_114434

Formulation

Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Label

Alexa Fluor 750 (Excitation= 749 nm, Emission= 775 nm)

Applications

Recommended Concentration

Sample

Western Blot

Optimal dilution of this antibody should be experimentally determined.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

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Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: Kremen-1

Kremen-1 is a type I transmembrane protein that contains extracellular Kringle, WSC, and CUB domains. It is expressed in diverse embryonic and adult tissues. Kremen proteins bind the secreted Dickkopf proteins Dkk-1, -2, and -4 with high affinity to antagonize the canonical Wnt signaling pathway.

Long Name

Kringle-containing Transmembrane Protein 1

Entrez Gene IDs

83999 (Human); 84035 (Mouse)

Alternate Names

EC 3.4.21; FLJ31863; KREMEM1; kremen protein 1; KREMEN; Kremen1; Kremen-1; kringle containing transmembrane protein 1; kringle containing transmembrane protein; Kringle domain-containing transmembrane protein 1; kringle-coding gene marking the eye and the nose; Kringle-containing protein marking the eye and the nose; KRM1; KRM1Dickkopf receptor