Human Latent TGF-beta bp2/LTBP-2 Alexa Fluor® 532-conjugated Antibody

Catalog #: FAB3850X Datasheet / COA / SDS

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FAB3850X-100UG

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All Latent TGF-beta bp2/LTBP-2 Antibodies

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Human Latent TGF-beta bp2/LTBP-2 Alexa Fluor® 532-conjugated Antibody Summary

Species Reactivity

Human

Specificity

Detects human Latent TGF‑ beta bp2/LTBP‑2 in direct ELISAs and Western blots. In direct ELISAs and Western blots, no cross-reactivity with recombinant mouse LTMP-4 is observed.

Source

Monoclonal Mouse IgG2b Clone # 327318

Purification

Protein A or G purified

Immunogen

Mouse myeloma cell line NS0-derived recombinant human Latent TGFâ€‘Î² bp2/LTBPâ€‘2
Gln36-Glu1821
Accession # NP_000419

Formulation

Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Label

Alexa Fluor 532 (Excitation= 534 nm, Emission= 553 nm)

Applications

Recommended Concentration

Sample

Western Blot

Optimal dilution of this antibody should be experimentally determined.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: Latent TGF-beta bp2/LTBP-2

LTBP-2 is a 240 kDa member of the LTBP and fibrillin families. Unlike other LTBP, LTBP-2 is not a component of the large latent TGF-beta complex. LTBP-2 is a secreted calcium-binding extracellular matrix glycoprotein of elastic tissue 10 nm microfibrils, especially in the lung. The 1786 aa mature human LTBP2 contains 20 EGF‑like domains and four 8-cysteine repeats and shares 80% aa identity with mouse LTBP-2. An RGD sequence and a proline-rich sequence may mediate adhesion of melanoma cells, but for fibroblasts LTBP-2 may actually be an antiadhesion protein. In vivo, proteolysis by plasmin and elastase is likely and may cleave putative adhesion sites.

Entrez Gene IDs

4053 (Human)

Alternate Names

C14orf141; GLC3D; Latent TGFbeta bp2; Latent TGF-beta bp2; latent transforming growth factor beta binding protein 2; latent-transforming growth factor beta-binding protein 2; LTBP2; LTBP-2; LTBP3chromosome 14 open reading frame 141; MSTP031