Human LKB1/STK11 Alexa Fluor® 750-conjugated Antibody

Applications

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Preparation and Storage

Background: LKB1/STK11

LKB1, also known as STK11 and JBS, is a 55 kDa member of the CAMK Ser/Thr protein kinase family. It is ubiquitously expressed, and considered to be a tumor suppressor. LKB1 is both nuclear and cytoplasmic, and appears to contribute to cell polarization, G1 cell cycle arrest and Wnt signaling. It is known to complex with STRAD and CAB39/MO25, and phosphorylate PTEN plus p53. Human LKB1 is 433 amino acids (aa) in length. It contains a protein kinase domain (aa 49‑309) and a prenylation motif (CysLysGlnGln) over aa 430‑433. Phosphorylation on Ser428 promotes the ability of LKB1 to suppress G361 cell growth. There are two potential isoforms of LKB1. One shows a nine aa insertion after Tyr126, while another shows a 34 aa substitution for aa 371‑433. Human LKB1 shares 90% aa sequence identity with mouse and rat LKB1.

Product Datasheets

Related Research Areas

• Cancer Biomarkers
• Epithelial Cell Polarity
• Intracellular Kinases in the Akt Pathway
• Intracellular Signaling Molecules in Angiogenesis
• Kinases and Phosphatases in VSMC
• p53 Pathway